Glucocorticoid Receptor β (GRβ): Beyond Its Dominant-Negative Function
نویسندگان
چکیده
منابع مشابه
Molecular origins for the dominant negative function of human glucocorticoid receptor beta.
This study molecularly elucidates the basis for the dominant negative mechanism of the glucocorticoid receptor (GR) isoform hGRbeta, whose overexpression is associated with human glucocorticoid resistance. Using a series of truncated hGRalpha mutants and sequential mutagenesis to generate a series of hGRalpha/beta hybrids, we find that the absence of helix 12 is neither necessary nor sufficient...
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Robert J.G. Haché, Joanne G.A. Savory and Yvonne A. Lefebvre Departments of Medicine, Biochemistry, Microbiology and Immunology, The Loeb Health Research Institute at the Ottawa Hospital, University of Ottawa, 725 Parkdale Ave., Ottawa, Ontario, Canada, K1Y 4K9 ______________________________________________________________________________________________________ 3 Correspondence: Robert J.G. Ha...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22073649